Singer, Jack W.; Abraham, Edward;

Method for treating hyperoxia

Disclosed are methods for treating conditions resulting from hyperoxia or mechanical ventilation comprising the administration of a compound of the formula: ##STR1## wherein R.sub.1 is a substantially pure resolved R enantiomer .omega.-1, secondary alcohol-substituted (C.sub.5-8) alkyl; and R.sub.2 and R.sub.3 are independently hydrogen atom or a (C.sub.1-12) alkyl optionally containing one or two oxygen atoms in place of non-adjacent carbon atoms.

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We claim:

1. A method for treating a condition resulting from hyperoxia comprising administering to an individual in need of such treatment a pharmaceutically effective amount of a compound of the formula ##STR12## wherein: R.sub.1 is a substantially pure resolved R enantiomer .omega.-1, secondary alcohol-substituted (C.sub.5-8) alkyl; and

R.sub.2 and R.sub.3 are independently hydrogen atom or a (C.sub.1-12) alkyl optionally containing one or two oxygen atoms in place of non-adjacent carbon atoms.

2. The method of claim 1 wherein the pharmaceutically effective amount is a prophylactically effective amount.

3. The method of claim 1 wherein the compound is 1-(R)-(5-hydroxyhexyl)-3,7-dimethylxanthine.

4. The method of claim 1 wherein the hyperoxia results from elevated inspired oxygen levels.

5. The method of claim 4 wherein the hyperoxia further results from elevated barometric pressure.

6. The method of claim 5 wherein the hyperoxia results from mechanical ventilation.

7. The method of claim 1 wherein the hyperoxia results from normal oxygen levels at ambient barometric pressure.

8. The method of claim 1 wherein the condition is selected from the group consisting of atelectasis, bronchopulmonary dysplasia, inflammation, tracheobronchitis, retinopathy of prematurity and seizures.

9. A method for treating conditions resulting from forced ventilation comprising administering to an individual in need of such treatment a pharmaceutically effective amount of a compound of the formula ##STR13## wherein: R.sub.1 is a substantially pure resolved R enantiomer .omega.-1, secondary alcohol-substituted (C.sub.5-8) alkyl; and

R.sub.2 and R.sub.3 are independently hydrogen atom or a (C.sub.1-12) alkyl optionally containing one or two oxygen atoms in place of non-adjacent carbon atoms.

10. The method of claim 9 wherein the compound is 1-(R)-(5-hydroxyhexyl)-3,7-dimethylxanthine.

11. The method of claim 9 wherein the condition results from mechanical ventilation.

12. The method of claim 9 wherein the pharmaceutically effective amount is a prophylactically effective amount.

13. The method of claim 9 wherein the condition is inflammation resulting from pulmonary cellular damage.